Childhood cancers differ fundamentally from adult cancers in causes, frequency, and course. Some forms of cancer occur exclusively in childhood.
Although many childhood cancers are well treatable by now, there are still no effective therapies for some other cancers. Moreover, many of the currently available therapies have far-reaching long-term side effects that young patients must live with until the end of their life.
It is a sad reality that the pharmaceutical industry shows little interest in paediatric cancer research because of poor economic profitability due to the low number of patients.
In order to reach the ultimate goal of one day curing childhood cancer without impairment of the quality of life for those affected, our research house is investigating the following questions:
- How does childhood cancer develop?
- How can the chances of cure be improved and late effects be avoided?
- Why does resistance to treatment occur and how can it be overcome
In order to find answers to these questions, the Frankfurt Foundation for Children with Cancer provides the Interdisciplinary Laboratory for Pediatric Tumor and Virus Research (IDL), headed by Prof. Dr. Jindrich Cinatl, and the Institute for Experimental Pediatric Hematology and Oncology, affiliated with the Goethe University Frankfurt and headed by Prof. Dr. Dirk Heckl, with state-of-the-art laboratories equipped with the latest technical equipment.
The Interdisciplinary Laboratory investigates, for example, why cancer cells in some types of paediatric cancer become resistant to the drugs used and with this information develop new strategies for overcoming this resistance. This research is carried out by means of a worldwide unique cell bank established by this laboratory.
Among other issues, the Institute for Experimental Pediatric Hematology and Oncology is investigating the question of why the naturally intended “suicide programme” for cancer cells does not work in children and adolescents.
This particular research in the Foundation’s research house is carried out in close connection and intensive exchange with doctors and scientists at the University Hospital Frankfurt am Main.
Another important concern of the Frankfurt Foundation for Children with Cancer is the promotion of young scientists. In this context the foundation has awarded the Dr. Maresch Klingelhöffer Prize to young scientists for the best scientific work in paediatric cancer research or related fields since 2008.
