The emergence of resistance to anti-cancer drugs is the main reason for failure in cancer therapy. The Interdisciplinary Laboratory for Paediatric Tumour and Virus Research focuses on investigating how cancer cells learn to resist chemotherapy and uses this information to develop new therapeutic approaches for treating cancers for which there are currently no suitable treatment options available.
Prof. Dr. Jindrich Cinatl and his research group began adapting cancer cells to antitumour agents more than 30 years ago. Since then, together with Prof. Dr. Martin Michaelis (University of Kent, Canterbury, UK), he has been running the Resistant Cancer Cell Line (RCCL) Collection, the world’s largest collection of drug-adapted cancer cell lines. Currently, the RCCL Collection comprises more than 2,500 therapy-resistant cancer cell lines that represent acquired resistance to more than 100 different drugs (as of July 2021).
The goal of the research is a better understanding of the underlying resistance mechanisms and, as a result, the new and further development of diagnostic procedures and therapy regimes for the treatment of children with cancer.
The RCCL Collection is used in cooperation with partners worldwide. The research of the Interdisciplinary Laboratory has contributed to concrete improvements in the treatment of various cancers.
Prof. Dr. Jindrich Cinatl received his doctorate after studying biology in Prague in 1985, where he worked as a Research Associate at the Institute of Haematology and Blood Transfusion at Charles University until 1986. From 1985 to 1987 he did research at the Department of Paediatrics and Adolescent Medicine at the Goethe University Hospital in Frankfurt and then continued his research at the Institute of Medical Virology in Frankfurt. After his habilitation, he headed the research department of the Institute of Medical Virology from 1998 to 2011. In 2001, he was appointed associate professor at the Medical Faculty of Goethe University. Since opening in 2005, Jindrich Cinatl’s working group “Interdisciplinary Laboratory for Paediatric Tumour and Virus Research” has been based in the Dr. Petra Joh House of the Frankfurt Foundation for Children with Cancer and conducts research on the development of new therapy concepts and treatment options for children and young people with cancer. Together with Prof. Dr. Martin Michaelis (University of Kent, Canterbury, UK), Prof. Cinatl heads the Resistant Cancer Cell Line (RCCL) Collection, the world’s largest collection of preclinical models for acquired resistance in cancer.
Prof. Dr. Martin Michaelis studied pharmacy and received his doctorate in pharmaceutical technology from the Goethe University in Frankfurt am Main. Afterwards, he worked first as a PostDoc and later as deputy head in the research group of Prof. Jindrich Cinatl at the Institute of Medical Virology at Goethe University Frankfurt and at the Dr. Petra Joh House of the Frankfurt Foundation for Children with Cancer. Since 2011, he has been Chair and Professor of Molecular Medicine at the University of Kent in Canterbury in the UK. Together with Jindrich Cinatl, Martin Michaelis heads the Resistant Cancer Cell Line (RCCL) Collection, the world’s largest collection of preclinical models for acquired resistance in cancer, and is the contact person for all enquiries.
Dr. Florian Rothweiler studied biology at the University of Frankfurt/Main from 1998 to 2003, followed by a doctorate in the working group of Prof. Cinatl. Since 2010, Dr. Rothweiler has been working in the Dr.Petra Joh-Haus of the Frankfurt Foundation for Children with Cancer and is the laboratory manager and deputy of Prof. Cinatl. Dr. Rothweiler is intensively involved in the maintenance, documentation and inventory of the Resistant Cancer Cell Line (RCCL) Collection.
After studying biology at the Goethe University in Frankfurt am Main, Dr. Jens-Uwe Vogel obtained his doctorate in 1996 in the working group of Prof. Jindrich Cinatl at the Institute of Medical Virology. Since the opening of the Dr. Petra Joh-Haus, he has been working as a group leader in the Interdisciplinary Laboratory for Paediatric Tumour and Virus Research. Here he is particularly concerned with virological issues in children with oncological diseases.
for children with cancer
Phone +49 (0)69 678665-0
Fax +49 (0)69 678665-94
Frankfurter Sparkasse 1822
IBAN: DE43 5005 0201 1245 6354 40
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