Career

In order to realise our research, we are continuously looking for young scientists who would like to become part of our team. By working on individual research projects, a contribution can be made to help children with cancer.

RESEARCH HELPS HEAL – Giving children with cancer a future.

Work together with us towards this goal and become part of the team. We are looking for ambitious and passionate employees for our pioneering tasks. The Frankfurt Foundation for Children with Cancer has an exceptional track record in educating and training the next generation of researchers in paediatric oncology. In addition to the positions advertised below, we always allow motivated students of medicine, biology and similar disciplines to accompany a translational research project as part of a final thesis.

Interdisciplinary Laboratory for Paediatric Tumour and Virus Research

PhD position (f/m/d)

The Interdisciplinary Laboratory (Head Prof. Jindrich Cinatl) focuses on tumour and virus research on a cell culture basis, especially on the development of chemoresistance in tumours, overcoming chemoresistance and the preclinical development of new therapies. To this end, a unique collection of adapted therapy-resistant cells has been established over the last 30 years, the Resistant Cancer Cell Line (RCCL) Collection.

The aim of all projects is to improve diagnostics and therapy, as well as the new and further development of diagnostic procedures and therapy regimes, especially for children with cancer. To this end, a translational approach is used to collaborate closely with clinicians and representatives of other disciplines (e.g. Nature Medicine, 23(2),250-55, 2017; Cancers (Basel).Apr 26;12(5):1080,2020; Commun Biol. Jun 24;3(1):324, 2020).

We are looking for a scientific PhD student. Experience in cell culture and molecular biology methods is desired. A Master’s degree (or similar) is required. Personal qualities such as teamwork, commitment and reliability are desired. The position is initially limited until 31.12.2023 (payment E 13 according to TV-GU).

Please send your application with relevant documents (cover letter, certificates from studies or previous employment, details of diploma or master’s thesis, as well as 2 references with contact details), preferably by email, as 1 PDF document to: f.rothweiler@kinderkrebsstiftung-frankfurt.de

Laboratory Assistant (f/m/d)

The Interdisciplinary Laboratory for Pediatric Tumor and Virus Research (lead by Prof. Jindrich Cinatl; Frankfurt Foundation for Children with Cancer) is interested in the underlying mechanism of chemoresistance, overcoming chemoresistance and developing new therapy strategies. To achieve this goal, a unique collection of resistant cancer cell lines (RCCL collection) was established over the last decades.

We are seeking applications for a laboratory assistant for the care and maintenance of the RCCL Collection. Experience in working with cell culture, cryopreservation of cell lines, viability assay, isolation of DNA and RNA and Western Blot are beneficial. We are looking for candidates who are highly self-motivated, dependable and organized team players. The position is a full-time employment, initially limited for one year with options for prolongation (payment according to TV-G-U).

Please send your application with relevant documents as 1 PDF document to:

f.rothweiler@kinderkrebsstiftung-frankfurt.de

Institute for Experimental Tumour Research in Paediatrics

MSc Projects in Molecular Cancer Research at the Institute for Experimental Cancer Research in Pediatrics

The Institute of Experimental Cancer Research in Pediatrics of the Johann Wolfgang Goethe-University Frankfurt am Main conducts fundamental and translational research in pediatric cancer and the underlying signaling pathways with the aim of identifying novel targets for cancer therapy.

The main research interest of the laboratory of Dr. Sjoerd van Wijk is to investigate how ubiquitination and autophagy control cell survival and cell death in healthy conditions and cancer. Our focus is on unravelling the biological functions and molecular mechanisms of how key enzymes in the ubiquitin pathway, like E3 ligases and deubiquitinating enzymes, are deregulated in pediatric cancers. In addition, we investigate the roles of autophagy in the regulation of cell death and are interested in understanding how death receptors control cell fate. For this, we apply highly inter-disciplinary approaches, including CRISPR/Cas9-mediated gene inactivation, advanced mass-spectrometry and high-content imaging using pediatric cancer cell lines, patient-derived material and preclinical mouse models.

Applications are open for motivated, talented and curious MSc students (Molecular Medicine, Molecular Biology, Biotechnology or Biology). Potential candidates with a completed BSc degree in a relevant field and with skills in cell and molecular biology are very welcome to apply. We are looking for candidates who are highly self-motivated, creative and organized team players who will join our young, international and dynamic research team. We offer an excellent supervision by an experienced PhD student or post-doc and exciting research in well-equipped research laboratories. MSc projects (6-12 months) can start immediately or at any time point, upon mutual agreement.

For more information:

Dr. Sjoerd van Wijk
Institute for Experimental Cancer Research in Pediatrics
Goethe University Frankfurt

Komturstr. 3a
60528 Frankfurt am Main

Tel. +49 (0)69 67866574
E-mail: s.wijk@kinderkrebsstiftung-frankfurt.de
Website: joerdjlvanwijk.de

MSc final project student in Apoptosis Signaling & Cancer

The Institute for Experimental Cancer Research in Pediatrics at the Goethe-University Frankfurt promotes translational cancer research. In particular we study apoptosis signaling pathways in cancers in order to identify key molecules for the development of new cancer therapeutics and novel prognostic biomarkers.

We are seeking applications for an enthusiastic, highly motivated MSc student in the field of Molecular Medicine, Molecular Biology, Human Biology or similar. Interested candidates must have a completed BSc degree in a relevant field and currently be enrolled in a MSc course at a German University. Applicants with skills in cell and molecular biology or experience in studying apoptosis are encouraged to apply. We are seeking candidates who are highly self-motivated to join a young, international and dynamic research team. According to the student’s requirement, the position can be filled immediately or at a later time point. The current project is designed for a final MSc dissertation project (6 – 12 months of lab work).

The lab of Dr. Meike Vogler is studying the regulation of apoptosis in cancer cells. Apoptosis resistance is one of the hallmarks of cancer. Apoptosis is controlled at the mitochondria by the B-Cell Lymphoma 2 (BCL2) protein family which facilitates the release of cytochrome c from the mitochondria into cytosol and the subsequent activation of caspases. BCL2, BCL-XL and MCL1 are frequently overexpressed in cancer and their role as important cellular oncogenes has been investigated in numerous studies. With the approval of Venetoclax, an anti-cancer therapeutic targeting BCL2, these BH3-mimetics have reached the clinic and are successfully used to treat leukemia.

Contact

Frankfurt Foundation
for children with cancer
Komturstraße 3a
60528 Frankfurt

Phone +49 (0)69 678665-0
Fax +49 (0)69 678665-94

info@kinderkrebsstiftung-frankfurt.de

Donation account

Frankfurter Sparkasse 1822
IBAN: DE43 5005 0201 1245 6354 40
SWIFT-BIC: HELADEF1822

Charity shopping

Make a good deed out of every online purchase and support the Frankfurt Foundation for Children with Cancer. It's easy to do so via Gooding or AmazonSmile.

Gooding

Here's how Gooding works:

AmazonSmile